Humulene

Article · Created: 2 Feb 2026 · Last edited: 2 Feb 2026
Humulene
Humulene
Chemical structure of Humulene
Field Value
Also Known As α-humulene, α-caryophyllene
Formula C₁₅H₂₄
Molar Mass 204.357 g/mol
Type Sesquiterpene
Boiling Point 106°C (223°F)

Humulene is a monocyclic sesquiterpene found abundantly in hops (Humulus lupulus) and in varying quantities in cannabis . It is responsible for the distinctive earthy, woody aroma associated with beer and contributes to the complex scent profile of many cannabis strains.

Aroma Profile

Humulene produces a distinctive combination of scents:

  • Earthy
  • Woody
  • Spicy
  • Herbal
  • Subtle hop-like bitterness

Natural Sources

Humulene is found in many plants beyond cannabis and hops:

  • Hops - Primary source, gives beer its characteristic aroma
  • Cannabis - Present in many strains
  • Black pepper - Contributes to its spicy notes
  • Sage - Part of its herbal scent
  • Ginseng - Traditional medicinal herb
  • Clove - Aromatic spice

Potential Benefits

Research suggests humulene may have several therapeutic properties:

  • Anti-inflammatory - Studies show potential for reducing inflammation
  • Appetite suppressant - Unlike many cannabinoids, may reduce appetite
  • Antibacterial - Shown activity against certain bacteria
  • Antitumor - Early research indicates possible anticancer properties

The Entourage Effect

Humulene often works synergistically with other terpenes and cannabinoids in what is known as the “entourage effect.” When combined with CBD or other compounds, its therapeutic potential may be enhanced.

Humulene in Cannabis Strains

Strains high in humulene typically have earthy, woody flavor profiles. Some strains known for elevated humulene content include:

  • Girl Scout Cookies
  • White Widow
  • Headband
  • Pink Kush
  • Sour Diesel

Relation to Hops

Humulene gets its name from Humulus lupulus, the scientific name for hops. Cannabis and hops are botanical relatives, both belonging to the family Cannabaceae . This shared ancestry explains why beer and certain cannabis strains can have similar aromatic qualities.

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